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changed the system prmpts

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Karthik Soman
2024-03-13 15:18:53 -07:00
parent 6639f77850
commit 2bf69100d0
2 changed files with 11 additions and 2 deletions
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kg_rag/rag_based_generation/GPT/drug_repurposing_v2.py
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@@ -39,7 +39,7 @@ To the question asked at the end, answer by referring the context.
See example below
Example 1:
Question:
What drugs can be repurposed to treat disease X?
What drugs can be repurposed for disease X?
Context:
Compound Alizapride DOWNREGULATES Gene APOE and Provenance of this association is XX. Gene APOE ASSOCIATES Disease X and Provenance of this association is YY. Gene TTR encodes Protein Transthyretin (ATTR) and Provenance of this association is ZZ. Compound Acetylcysteine treats Disease X and Provenance of this association is PP.
Answer:

11
system_prompts.yaml
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@@ -97,7 +97,7 @@ DRUG_REPURPOSING_V2: |
Reason with quantitative evidence, if possible (i.e. incuding statistical values if available).
For example:
Question:
What drugs can be repurposed to treat disease X?
What drugs can be repurposed for disease X?
Context:
Compound X DOWNREGULATES Gene Y and Provenance for this information is XX.
Gene Y ASSOCIATES Disease X and Provenance for this information is YY.
@@ -105,3 +105,12 @@ DRUG_REPURPOSING_V2: |
Gene Z ASSOCIATES Disease X and Provenance for this information is PP.
Answer:
Since Compound X downregulates Gene Y (provenance is XX) and Gene Y is associated with Disease X (provenance YY), Compound X can be repurposed to treat Disease X. Since Compound Y upregulates Gene Z (Provenance ZZ) and Gene Z is associated with Disease X (Provenance PP), Compound Y can be repurposed to treat Disease X.
Another example:
Question:
What drugs can be repurposed for disease X?
Context:
Compound XX UPREGULATES Gene ZZ and Provenance for this information is ZZZZ, z-score is YYYY.
Gene ZZ ASSOCIATES Disease YY and Provenance for this information is QQQQ, p-valUe is PPPP.
Answer:
Since Compound upregulates gene ZZ (Provenance ZZZZ, z-score YYYY) and Gene ZZ associates disease YY (Provenance QQQQ, p-value is PPPP.